Pi-Wan Cheng | Molecular Biology | Best Researcher Award

Prof. Dr. Pi-Wan Cheng | Molecular Biology | Best Researcher Award

Professor at University of Nebraska Medical Center, United States

Dr. Pi Wan Cheng is a distinguished biochemist and molecular biologist with over four decades of experience in research and academia. He currently holds a professorship at the University of Nebraska Medical Center (UNMC) and has contributed significantly to the field of glycobiology. Dr. Cheng has made pivotal advancements in understanding glycan biosynthesis and its role in health, diseases, and cancer. His work, which bridges basic and translational research, is supported by multiple research grants and patents. He has also been an active member of several professional organizations, underscoring his influence in the scientific community. Dr. Cheng’s research focuses on how glycosylation affects immune responses and cancer progression, with a special emphasis on the development of Siglec-7-based therapies for pancreatic cancer.

Professional Profile

Education:

Dr. Pi Wan Cheng obtained his Ph.D. in Biochemistry from Case Western Reserve University, Cleveland, Ohio, in 1975. Prior to that, he earned his M.S. in Biochemistry from National Taiwan University in 1968, following his B.S. in Agricultural Chemistry from the same institution in 1965. Throughout his educational journey, Dr. Cheng worked under the mentorship of prominent scientists such as Dr. Don M. Carlson and Dr. Kuo Huang Ling, which shaped his academic and professional growth in biochemistry and molecular biology.

Professional Experience:

Dr. Cheng’s career spans numerous prestigious academic institutions. He has held faculty positions at Case Western Reserve University, the University of North Carolina, and UNMC. At UNMC, he has been a professor in the Department of Biochemistry and Molecular Biology since 1995, where he was granted tenure in 1997. He also served as a research chemist at the Veterans Affairs Nebraska Western Iowa Health Care System from 2011 to 2017. His role at UNMC also includes courtesy appointments in the College of Pharmacy and the Eppley Institute for Cancer Research, where he has fostered collaborations and contributed to the institution’s research landscape.

Research Interest:

Dr. Cheng’s primary research interest lies in glycobiology, specifically the mechanisms of glycan biosynthesis and its impact on health and disease. His work focuses on understanding how glycans, particularly sialylated O-glycans, influence immune responses and contribute to the progression of diseases such as cancer. He investigates how specific glycans, induced by factors like interleukin-6 and alcohol, can protect cancer cells from immune surveillance and promote tumor growth. His innovative research is also exploring therapies targeting Siglec-7 for pancreatic cancer treatment, with potential applications in immunotherapy and cancer prevention.

Research Skills:

Dr. Cheng possesses a comprehensive skill set in biochemistry, molecular biology, and glycobiology. He is skilled in techniques related to protein biochemistry, glycan analysis, immunology, and cancer research. His expertise includes the development of molecular models to understand glycan interactions with immune cells, as well as employing various biochemical assays to assess glycan expression in disease states. Dr. Cheng’s proficiency extends to experimental design, grant writing, and leading interdisciplinary research teams. He has also contributed to the field through patents, underscoring his ability to translate fundamental discoveries into real-world applications.

Awards and Honors:

Throughout his career, Dr. Cheng has received numerous accolades for his groundbreaking research in glycobiology. His work has been supported by prestigious grants, including those from the Nebraska Department of Health and Human Services, where he has led multiple research projects related to cancer and immune function. He holds patents in biologically active molecule delivery, reflecting his innovative contributions to science. Dr. Cheng is a lifetime member of the Society for Glycobiology and the Society of Chinese Bioscientists in America, and he has been recognized for his service to the scientific community through various professional society memberships and community volunteer work.

Conclusion:

Dr. Pi Wan Cheng is a highly qualified candidate for the Best Researcher Award, with a distinguished career marked by significant research contributions in glycobiology, a track record of continuous funding, and active involvement in the scientific community. His innovative research, particularly in cancer immunology and glycosylation, holds great promise for medical advancements. While there is room for further interdisciplinary collaboration and publication visibility, his foundational work in glycobiology makes him a deserving nominee for this prestigious award.

Publication Top Notes

  1. Markers of malignant prostate cancer cells: Golgi localization of α-mannosidase 1A at GM130-GRASP65 site and appearance of high mannose N-glycans on cell surface
    • Authors: Cheng, P.-W., Davidson, S., Bhat, G.
    • Year: 2020
    • Citations: 12
  2. Inhibitory activity of salivary glycoproteins on phytohemagglutins (PHA): Possible molecules to enhance nutritional quality of red kidney beans
    • Authors: Chachadi, V.B., Nayanegali, T.R., Pujari, B.G., Inamdar, S.R., Cheng, P.-W.
    • Year: 2020
    • Citations: 3
  3. p66Shc protein through a redox mechanism enhances the progression of prostate cancer cells towards castration-resistance
    • Authors: Miller, D.R., Ingersoll, M.A., Chatterjee, A., Oberley-Deegan, R.E., Lin, M.-F.
    • Year: 2019
    • Citations: 18
  4. Shifted Golgi targeting of glycosyltransferases and α-mannosidase IA from giantin to GM130-GRASP65 results in formation of high mannose N-glycans in aggressive prostate cancer cells
    • Authors: Bhat, G., Hothpet, V.-R., Lin, M.-F., Cheng, P.-W.
    • Year: 2017
    • Citations: 18
  5. The role of Rab6a and phosphorylation of non-muscle myosin IIA tailpiece in alcohol-induced Golgi disorganization
    • Authors: Petrosyan, A., Casey, C.A., Cheng, P.-W.
    • Year: 2016
    • Citations: 22
  6. Downregulation of the small GTPase SAR1A: A key event underlying alcohol-induced Golgi fragmentation in hepatocytes
    • Authors: Petrosyan, A., Cheng, P.-W., Clemens, D.L., Casey, C.A.
    • Year: 2015
    • Citations: 20
  7. Glycosyltransferases involved in the synthesis of MUC-associated metastasis-promoting selectin ligands
    • Authors: Chachadi, V.B., Bhat, G., Cheng, P.-W.
    • Year: 2015
    • Citations: 15
  8. Keratin 1 plays a critical role in Golgi localization of core 2 N-acetylglucosaminyltransferase M via interaction with its cytoplasmic tail
    • Authors: Petrosyan, A., Ali, M.F., Cheng, P.-W.
    • Year: 2015
    • Citations: 20
  9. Restoration of compact Golgi morphology in advanced prostate cancer enhances susceptibility to galectin-1-induced apoptosis by modifying mucin O-glycan synthesis
    • Authors: Petrosyan, A., Holzapfel, M.S., Muirhead, D.E., Cheng, P.-W.
    • Year: 2014
    • Citations: 64
  10. Golgi fragmentation induced by heat shock or inhibition of heat shock proteins is mediated by non-muscle myosin IIA via its interaction with glycosyltransferases
    • Authors: Petrosyan, A., Cheng, P.-W.
    • Year: 2014
    • Citations: 24

 

Xiumin Wang | Molecular Biology | Women Researcher Award

Prof. Dr. Xiumin Wang | Molecular Biology | Women Researcher Award

Researcher at Feed Research Institute, Chinese Academy of Agricultural Sciences, China

Dr. Wang Xiumin is a distinguished researcher currently serving at the Institute of Feed Research, Chinese Academy of Agricultural Sciences (CAAS). With a profound academic background and extensive research experience in the field of plant pathology and microbial resistance, Dr. Wang has become a leading figure in her field. Over her career, she has focused on microbial resistance, antibacterial peptides, and the development of therapeutic strategies to combat infectious diseases, especially those involving multi-drug resistant pathogens. Dr. Wang’s work has been instrumental in bridging the gap between fundamental microbiology and applied agricultural practices, contributing to the development of feed-related solutions and sustainable agricultural practices. Her research is widely recognized through numerous publications in prestigious scientific journals, where she has co-authored over 80 papers.

Professional Profile

Education:

Dr. Wang Xiumin obtained her Ph.D. in Plant Pathology from Northwest Agriculture & Forestry University in 2006, after completing her Master’s and Bachelor’s degrees at the same institution in 2003 and 2000, respectively. Her academic training equipped her with in-depth knowledge in plant protection and pathology, laying a strong foundation for her career in agricultural sciences and microbiology. Her academic journey enabled her to focus on plant diseases, microbiology, and biotechnology, advancing her research in combating bacterial resistance in agricultural systems.

Professional Experience:

Dr. Wang Xiumin has accumulated extensive professional experience across various prestigious institutions. From 2006 to 2009, she worked as a Postdoctoral Fellow at Beijing Forestry University, engaging in critical research in plant pathology. Between 2009 and 2013, she served as an Assistant Researcher at the Feed Research Institute of CAAS. Since 2013, she has held the position of Associate Researcher at the same institute. In 2019-2020, she visited the School of Chemistry and Molecular Biosciences at the University of Queensland, further enhancing her expertise in molecular biosciences and plant pathology. Throughout her career, Dr. Wang has continually advanced her research while mentoring emerging scientists in her field.

Research Interests:

Dr. Wang’s research interests lie at the intersection of microbial resistance, plant pathology, and feed-related research. Her work primarily focuses on antibacterial peptides, microbial resistance mechanisms, and the development of therapeutic proteins and peptides. She has also contributed to studies on food safety, including the detoxification of mycotoxins, and has explored the therapeutic potential of marine peptides for bacterial infections. Dr. Wang’s research in microbial resistance and peptide-based therapeutics is crucial for advancing sustainable agricultural and clinical practices, particularly in the context of combating drug-resistant pathogens in both animals and humans.

Research Skills:

Dr. Wang Xiumin is highly skilled in a variety of research techniques including molecular biology, microbiology, and biotechnology. She has experience in the design and application of antibacterial peptides, the isolation and characterization of bioactive compounds, and the assessment of microbial resistance mechanisms. Her expertise also extends to advanced techniques in molecular cloning, protein expression, and peptide synthesis. Additionally, Dr. Wang is adept at using in vitro and in vivo models to study the effects of therapeutic peptides and other compounds on microbial infections. Her diverse skill set has been pivotal in advancing her research projects and making significant contributions to agricultural and health sciences.

Awards and Honors:

Dr. Wang Xiumin has received several accolades for her outstanding contributions to the field of plant pathology and microbiology. She has been recognized for her innovative research in microbial resistance and peptide-based therapeutics, receiving awards from various scientific and agricultural bodies in China. Her significant publications in high-impact journals such as Science of the Total Environment, Journal of Medicinal Chemistry, and Food Chemistry have cemented her reputation as a leading researcher in her field. Additionally, her collaborative work with international research institutes has earned her several fellowships, including her research visit to the University of Queensland, further acknowledging her impact on global agricultural science and medical microbiology.

Conclusion

Dr. Wang Xiumin demonstrates a strong and well-rounded research profile, with impressive publications and a proven ability to address complex issues in plant pathology and antimicrobial resistance. His work is highly relevant and impactful in agricultural and biomedical fields. His contributions place him as a strong candidate for the Excellence in Research Award. Expanding his industry collaborations and mentoring roles would elevate his profile further, making him an even more influential figure in his field.

Publication Top Notes

  1. Application of Lactobacillus plantarum and Pediococcus lactis on Lipid Metabolism, Anti-Inflammatory, and Fecal Microbiota in Cats
    • Authors: Shukun Liang, Xinshu Gu, Jintao Sun, Xiumin Wang, Hui Tao, Zhenlong Wang, Yougang Zhong, Jinquan Wang, Bing Han
    • Year: 2024
    • DOI: 10.3390/microorganisms12122446
  2. Application of Network Pharmacology, Molecular Docking, and In Vitro Experimental Evaluation to Decipher the Anti-Inflammatory Mechanisms of Cirsium japonicum
    • Authors: Jiaxue Wang, Hui Tao, Zhenlong Wang, Wei An, Ya Zhao, Bing Han, Jinquan Wang, Xiuzhu Sun, Xiumin Wang
    • Year: 2024
    • DOI: 10.3390/app14219687
  3. Simultaneous Degradation of AFB1 and ZEN by CotA Laccase from Bacillus subtilis ZJ-2019-1 in the Mediator-Assisted or Immobilization System
    • Authors: Boquan Gao, Wei An, Jianwen Wu, Xiumin Wang, Bing Han, Hui Tao, Jie Liu, Zhenlong Wang, Jinquan Wang
    • Year: 2024
    • DOI: 10.3390/toxins16100445
  4. Allergies to Allergens from Cats and Dogs: A Review and Update on Sources, Pathogenesis, and Strategies
    • Authors: Wei An, Ting Li, Xinya Tian, Xiaoxin Fu, Chunxiao Li, Zhenlong Wang, Jinquan Wang, Xiumin Wang
    • Year: 2024
    • DOI: 10.3390/ijms251910520
  5. Bacillus subtilis Simultaneously Detoxified Aflatoxin B1 and Zearalenone
    • Authors: Jianwen Wu, Zhenlong Wang, Wei An, Boquan Gao, Chunxiao Li, Bing Han, Hui Tao, Jinquan Wang, Xiumin Wang, Huanrong Li
    • Year: 2024
    • DOI: 10.3390/app14041589
  6. The Effect of Lactobacillus plantarum on the Fecal Microbiota, Short Chain Fatty Acids, Odorous Substances, and Blood Biochemical Indices of Cats
    • Authors: Bing Han, Shukun Liang, Jintao Sun, Hui Tao, Zhenlong Wang, Baosheng Liu, Xiumin Wang, Jie Liu, Jinquan Wang
    • Year: 2024
    • DOI: 10.3390/microorganisms12010091
  7. Comparison Study of Two Fumonisin-Degrading Enzymes for Detoxification in Piglets
    • Authors: Zhenlong Wang, Zonghao Lv, Tibor Czabany, Veronika Nagl, Rudolf Krska, Xiumin Wang, Bing Han, Hui Tao, Jie Liu, Jinquan Wang
    • Year: 2023
    • DOI: 10.3390/toxins16010003
  8. The Effect of Duck Bile Acid Extract on the Fecal Microbiota, Short Chain Fatty Acids, Fat Digestibility and Blood Biochemical Indices in Cats
    • Authors: Bing Han, Peng Zhao, Shukun Liang, Zhenlong Wang, Hui Tao, Xiumin Wang, Jie Liu, Jinquan Wang
    • Year: 2023
    • DOI: 10.3390/app13179713
  9. A Screening Model of Antibacterial Agents Based on Escherichia coli Cell-Division Protein
    • Authors: Qiuyu Fan, Jianwen Wu, Bolin Xi, Chunxiao Li, Xiumin Wang, Huanrong Li
    • Year: 2023
    • DOI: 10.3390/app13074493
  10. Mini-Review: Antibiotic-Resistant Escherichia coli from Farm Animal-Associated Sources
    • Authors: ChunMing Xu, Lingqiang Kong, Yonghong Liao, Yuan Tian, Qi Wu, Haosi Liu, Xiumin Wang
    • Year: 2022
    • DOI: 10.3390/antibiotics11111535